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(Fading puppy syndrome)
(Neonatal death syndrome)
There is in the veterinary literature much
about herpes infection in dogs, many excellent articles have been published.
Anyone wishing a quick look, got to any veterinary
hospital or library and ask for:
* VETERINARY INTERNAL MEDICINE
* THE ROLE OF NEONATAL CANINE HERPES VIRUS
INFECTION IN MIXED
INFECTIONS IN OLDER DOGS
Continuing Education Article
688 Vol. 8 No. 10, October
None of these or other articles addresses the
problems of treatment and prevention of death!
We cannot at this time prevent
the death of prenatal pups in uterus by the virus. It seems to infect
the placenta and kills the pup during the later stages of gestation.
The pups are born dead, autolyzed, infected with fecal bacteria, and in
some cases inclusions can be found by pathologists in the placental tissue.
We hope some day to be able to address this problem.
NEONATAL HERPES PUPPIES
The usual presentation to veterinarians
is with one or more puppies dead, some dying and others not yet sick or
showing symptoms. All dead puppies should be autopsied. Lesions
can usually be found in the lungs, kidneys, intestines, and liver (see
TREATMENT OF SICK LITTERS
Newborn puppies from suspected
kennels or dams with herpes virus can be treated with a subcutaneous injection
of 1c.c. of Distemper anti viral serum given to each puppy immediately
after birth and repeated 24 hours later. This will dramatically reduce
the death rate.
TREATMENT OF INDIVIDUAL PUPPIES ILL WITH
Until recently all puppies
manifesting herpes illness died within a very short period of time, usually
within a few hours of showing symptoms. There are however two techniques
for the treatment of these puppies that have had considerable success.
Technique by: A.W.
each puppy every 12 hours for 36 hours, (3 doses).
Puppy should weigh between 1 and 3 pounds
DISTEMPER ANTI VIRAL SERUM:
Administer 1 c.c. subcutaneously to
hour for 3 hours, (To control loss of potassium).
Lasix: One drop orally, (To
control lung edema)
Kaon (Potassium Gluconate elixir):
Administer one drop orally every
(to control lung infection).
Chloromycetin: Administer 0.05c.c.
orally once daily,
neonatal puppy formulas.
(Photos of puppies treated with above
Gancylovir: Administer 0.1 c.c.
subcutaneously to each puppy.
Incubator: Keep puppies in incubator
at 96 degrees for 24 hours.
Fluids: Give plenty of fluids
orally, sugar water works well, as do
Ronald Bell, DVM
water. The powder will not dissolve but is suspended. Administer
Puppy should weigh between 2 and 3 pounds.
Acyclovir powder in capsules:
Mix 200 mg capsule in 10c.c. of warm
0.5 c.c. (10 mg) to each puppy every 6 hours until puppies are
3 1/2 weeks old.
Place in incubator.
Give fluids orally
Treatment of puppies does
not guarantee that reproductive lesions will not
appear before puberty. Lesions are found
both in the prepuce (balanophthitis) and vagina, however, no reproductive
symptoms have been observed in the treated puppies.